Lane made her screen debut in George Roy Hill's 1979 film A Little Romance.

She has since appeared in several notable films, including the 2002 film Unfaithful, which earned her Satellite, New York Film Critics Circle, and National Society of Film Critics awards for Best Actress in a Motion Picture (Drama).

In 2002, she starred in Unfaithful, a drama film directed by Adrian Lyne and adapted from the French film The Unfaithful Wife.

Lane played a housewife who indulges in an adulterous fling with a mysterious book dealer.

Thomas Howell, Emilio Estevez, Patrick Swayze, Mickey Rourke, Nicolas Cage, and Matt Dillon.

Lane's distinction among these heavily male casts advanced her career while affiliating her with this young generation of male actors.

The play of lust, romance, degradation, and guilt on her face is the movie's real story." Following Unfaithful, Lane starred in Under the Tuscan Sun, a film based on the best-selling book by Frances Mayes for which Lane won a further Best Actress Golden Globe nomination.

This was followed by lead roles in Fierce People, Must Love Dogs, and Hollywoodland.In 1981, she enrolled in high school after taking correspondence courses.However, Lane's mother kidnapped her and took her back to Georgia.Lane and her father challenged her mother in court, and six weeks later, she was back in New York.Lane did not speak to her mother for the next three years, but they eventually reconciled.She played Martha Kent in Man of Steel, Batman v Superman: Dawn of Justice, and Justice League. Her mother, Colleen Leigh Farrington, was a nightclub singer and Playboy centerfold (Miss October 1957), who was also known as "Colleen Price".